Emmanuelle Passegué, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
passegue_emmanuelle

Associate Professor, Department of Medicine (Division of Hematology/Oncology); Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF

passeguee@stemcell.ucsf.edu

Phone: (415) 476-2426 (voice)
Box 0667, UCSF
San Francisco, CA 94143-0667

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Additional Websites


Education

Paris-XI University, Paris, France, B.S., 1990, Molecular Biology
Paris-XI University, Paris, France, Diploma, 1991, Endocrinology
Paris-XI University, Paris, France, Ph.D., 1995, Endocrinology
IMP, Vienna, Austria, Mouse genetics
Stanford University, Stanford, CA, Stem cell biology


Professional Experience

  • 1991-1995
    Graduate student, College de France, Paris, France
  • 1996-2000
    Postdoctoral fellow, Institute of Molecular Pathology (IMP), Vienna, Austria
  • 2001-2003
    Postdoctoral fellow, Department of Pathology, Stanford University, CA
  • 2003-2005
    Research Associate, Department of Pathology, Stanford University, CA
  • 2005-2010
    Assistant Professor, Department of Medicine, Division of Hematology/Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA
  • 2010-present
    Associate Professor, Department of Medicine, Division of Hematology/Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA

Honors & Awards

  • 2001
    Long-term EMBO postdoctoral fellowship
  • 2002
    Jose Carreras International Leukemia Foundation postdoctoral fellowship (FIJC-01/EDTHOMAS)
  • 2007
    ASH Scholar Award
  • 2008
    Rita Allen Scholar Award
  • 2008
    CIRM New Investigator Award

Selected Publications

  1. Kohli L, Passegué E. Surviving change: the metabolic journey of hematopoietic stem cells. Trends Cell Biol. 2014 Aug; 24(8):479-87.
    View on PubMed
  2. Pietras EM, Lakshminarasimhan R, Techner JM, Fong S, Flach J, Binnewies M, Passegué E. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med. 2014 Feb 10; 211(2):245-62.
    View on PubMed
  3. Bakker ST, Passegué E. Resilient and resourceful: Genome maintenance strategies in hematopoietic stem cells. Exp Hematol. 2013 Nov; 41(11):915-23.
    View on PubMed
  4. Pietras EM, Passegué E. Linking HSCs to their youth. Nat Cell Biol. 2013 Aug; 15(8):885-7.
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  5. Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell. 2013 Sep 5; 13(3):285-99.
    View on PubMed
  6. Warr MR, Kohli L, Passegué E. Born to survive: autophagy in hematopoietic stem cell maintenance. Cell Cycle. 2013 Jul 1; 12(13):1979-80.
    View on PubMed
  7. Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7.
    View on PubMed
  8. Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC. Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations. Leukemia. 2013 Jul; 27(7):1570-3.
    View on PubMed
  9. Warr MR, Passegué E. Metabolic makeover for HSCs. Cell Stem Cell. 2013 Jan 3; 12(1):1-3.
    View on PubMed
  10. Schepers K, Hsiao EC, Garg T, Scott MJ, Passegué E. Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood. 2012 Oct 25; 120(17):3425-35.
    View on PubMed
  11. Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. Stem cells assessed. Nat Rev Mol Cell Biol. 2012 Jul; 13(7):471-6.
    View on PubMed
  12. Smith-Berdan S, Schepers K, Ly A, Passegué E, Forsberg EC. Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations. Cell Cycle. 2012 Feb 15; 11(4):675-82.
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  13. Pietras EM, Warr MR, Passegué E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011 Nov 28; 195(5):709-20.
    View on PubMed
  14. Reynaud D, Pietras E, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell. 2011 Nov 15; 20(5):661-73.
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  15. Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI. Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev. 2011 Aug 15; 25(16):1746-57.
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  16. Warr MR, Pietras EM, Passegué E. Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):681-701.
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  17. Blanpain C, Mohrin M, Sotiropoulou PA, Passegué E. DNA-damage response in tissue-specific and cancer stem cells. Cell Stem Cell. 2011 Jan 7; 8(1):16-29.
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  18. Elefanty AG, Blelloch R, Passegué E, Wernig M, Mummery CL. On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010. Cell Stem Cell. 2010 Oct 8; 7(4):443-50.
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  19. Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 2010 Nov 1; 70(21):8792-801.
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  20. Ragu C, Elain G, Mylonas E, Ottolenghi C, Cagnard N, Daegelen D, Passegué E, Vainchenker W, Bernard OA, Penard-Lacronique V. The transcription factor Srf regulates hematopoietic stem cell adhesion. Blood. 2010 Nov 25; 116(22):4464-73.
    View on PubMed

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